Hosting at home is a big mistake although, if you have the resources like an in-house server / network / linux specialist and around Ł15000 (last time I checked) a year to get a half decent pipe routed to your location, it is an option.
We prefer to leave our hosting to Rackspace with their 247 fanatical freephone telephone support, they really do bend over backwards to help.
When you call them, you are usually put through to an engineer that has access to your machine and will help you there and then.
I can't sing their praises highly enough really which is why we now have 2 servers with them and I can sleep at night
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